Table 3.
The concentration of paracetamol and its metabolites in plasma after acute (single dose; E19) or chronic (5 day twice daily; E15–E19) maternal injection of 15 mg/kg paracetamol.
| Paracetamol | Paracetamol-glutathione | Paracetamol-glucuronide | Paracetamol-sulphate | |||||
|---|---|---|---|---|---|---|---|---|
| Acute | Chronic | Acute | Chronic | Acute | Chronic | Acute | Chronic | |
| Maternal plasma | 42 μM | 40 μM | 72 nM | 88 nM | 53 μM | 101 μM | 171 μM | 208 μM |
| Fetal plasma | 22 μM ± 4 | 18 μM ± 5 | N.D. | N.D. | 14 μM ± 2 | 6 μM ± 4 | 40 μM ± 11 | 17 μM ± 6 |
Fetal results are ± S.D. For animal numbers see Fig. 2.
N.D. not detected.