Table 4.

The concentration of paracetamol and its metabolites in plasma after acute (single dose; E19) or chronic (5 day twice daily; E15–E19) maternal injection of 3.75 mg/kg paracetamol.

	Paracetamol		Paracetamol-glutathione		Paracetamol-glucuronide		Paracetamol-sulphate
	Acute	Chronic	Acute	Chronic	Acute	Chronic	Acute	Chronic
Maternal plasma	10 μM	10 μM	24 nM	N.D.	13 μM	18 μM	43 μM	83 μM
Fetal plasma	7 μM ± 1	11 μM ± 4	N.D.	N.D.	2 μM ± 1	3 μM ± 2	8 μM ± 3	9 μM ± 5

Fetal results are ± S.D, for animal numbers see Fig. 2.

N.D. not detected.