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. 2021 Oct 6;11:19871. doi: 10.1038/s41598-021-99237-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of MPTP and L-DOPA treatment on COMT in the monkey heart. (A, B) MB-COMT/β-actin ratio (optical density, % vs control) in controls, MPTP-treated monkeys and in the MPTP + L-DOPA group. MB-COMT expression was increased in the RV of MPTP- and MPTP + L-DOPA-treated animals compared to control group. (C) Significant correlation between MB-COMT and TH+ neurons in the SNpc (r² = 0.71, P = 0.0046). (D, E) S-COMT/β-actin ratio (optical density, % vs control) in controls, MPTP-treated monkeys and in the MPTP + L-DOPA group. The quantitative analysis showed no differences between groups. (F) No correlation between S-COMT and TH+ neurons in the SNpc was observed. Data were compared by one-way ANOVA (MB-COMT: F_(2,9) = 14.41, P = 0.0016, RV; F_(2,9) = 11.62, P = 0.0032, LV. S-COMT: F_(2,9) = 3.31, P = 0.0827, RV; F_(2,9) = 1.742, P = 0.2293, LV) followed by Newman–Keuls post-hoc test. Values are represented as mean ± standard deviation. (*P < 0.05, **P < 0.01, ***P < 0.001 versus control group). MB membrane, S soluble, COMT catechol-O-methyl transferase, MPTP 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, L-DOPA levodopa. (n = 4 animals/group and 2 technical replicates/animal).