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. 2021 Oct 6;11:19873. doi: 10.1038/s41598-021-99321-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Gene–drug interaction network of the CTHRC1 and chemotherapeutic drugs. Red arrows: chemotherapeutic drugs increase the expression of CTHRC1; green arrows: chemotherapeutic drugs decrease the expression of CTHRC1. The numbers of arrows between chemotherapeutic drugs and key genes in this network represent the supported numbers of literatures by previous reports.