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. 2021 Oct 6;11:19808. doi: 10.1038/s41598-021-99407-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(a) chart showing the effect of pH change on the zeta potential values of developed NMOFs formulas, (b) In-vitro drug release from LA-GA-NMOF at different pHs (4 and 7.4) with a focus on the release profile during the first 3 h (inset), (c) cytocompatibility study using HSF cells post-treatment with different concentrations of pristine NMOF for 72 h. (d, e) HepG2 cell viabilities post-incubation with free DOX and DOX-loaded NMOFs for 24 h (d) and 48 h (e).