Table 1.
Indicating both of entrapment efficiency, loading capacity of DOX. HCL to NMOF and FA-NMOF, LA-NMOF, GA-NMOF L-G-NMOF, and cytotoxicity activity of DOX loaded formulations at two-time intervals, (24, 48 h).
| Formula | EE % | LC % | IC50/24 h ± SD | IC50/48 h ± SD |
|---|---|---|---|---|
| NMOF | 50.63 ± 0.96 | 15.59 ± 0.03 | 5.982 ± 0.4 | 2.16 ± 0.16 |
| FA-NMOF | 29.77 ± 0.11 | 9.40 ± 0.05 | 1.887 ± 0.05 | 0.838 ± 0.05 |
| LA-NMOF | 30.98 ± 0.06 | 9.84 ± 09 | 0.641 ± 0.03 | 0.487 ± 0.07 |
| GA-NMOF | 31.63 ± 0.02 | 9.95 ± 02 | 0.986 ± 0.08 | 0.492 ± 0.05 |
| LA-GA-NMOF | 19.73 ± 0.71 | 6.26 ± 04 | 0.52 ± 0.15 | 0.32 ± 0.08 |
| Free DOX | 1.2 ± 0.25 | 0.1 ± 0.02 | ||