Table 3:

Adjusted hazard ratios of opioid related events and adjusted odds ratios for buprenorphine fills in 12 months after discontinuation or dose reduction, according to opioid dose trajectory

	Risk of any event	Risk of suicide	Risk of overdose	Risk of Adverse events	Buprenorphine Filled
	aHR (95% CI)*	aHR (95% CI)*	aHR (95% CI)*	aHR (95% CI)*	aOR (95% CI)*
Stable or increasing dose	Reference	Reference	Reference	Reference	Reference
Abrupt discontinuation	1.22 (0.94–1.58)	3.63 (1.42–9.25)	0.62 (0.40–0.94)	1.61 (1.15–2.26)	15.07 (7.28–38.38)
Dose reduction and discontinuation	1.13 (0.84–1.53)	4.47 (1.68–11.88)	0.36 (0.20–0.66)	1.54 (1.05–2.25)	14.83 (7.00–38.33)
Dose reduction without discontinuation	0.94 (0.73–1.21)	1.29 (0.48–3.45)	0.41 (0.27–0.62)	1.45 (1.04–2.02)	2.47 (1.14–6.46)

aHR: adjusted hazard ratio; OR: odds ratio, CI: confidence interval

^*Adjusted for age, gender, race, rurality, comorbidities, MME dose, filled benzodiazepines, chronic pain