Fig. 2. Expression correlations of DE genes: scRNA-seq data from five lung adenocarcinoma cell lines²⁸.

a Average expression of top 10 DE genes for each cell line. b Gene–gene correlations of the same genes. c Gene–gene correlations for non-DE genes. d Boxplot showing correlation range scores for non-DE and DE genes. DE gene computation is detailed in Supp. Note 1A. The middle line is the median, the lower and upper box limits correspond to the first and third quartiles, the upper and lower whiskers extend upto 1.5*IQR from the top and bottom of the box, respectively (where IQR is the inter-quartile range), and data beyond the ends of the whiskers are outlying points that are plotted individually. P-value was calculated using two-sided Wilcoxon test (n = 8602 expressed genes). e, f Scatter plot of genes showing correlation between e log2(fold change) of cell-type-specific expression and f −log10(q-value) of cell-type-specific expression with correlation range score. ρ: Spearman correlation.