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. 2021 Oct 6;12:5862. doi: 10.1038/s41467-021-26142-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, b Immortalized WT and Nlrp3^−/− BMDMs reconstituted with doxycycline-inducible NLRP3 mutants were sequentially treated with doxycycline, LPS, and nigericin or ATP as indicated. IL-1β and TNF secretions were measured by ELISA. NLRP3 R258W was used as a constitutively active control. Means and 1 SD are represented. Data are biological duplicates representative of 4 (a) and 3 (b) independent experiment. pInd pInducer21, iBMDMs immortalized BMDMs.