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. 2021 Oct 6;12:5862. doi: 10.1038/s41467-021-26142-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Nlrp3^S803D/S803D and Nlrp3^+/+ littermates were injected intraperitoneally with LPS. a Indicated cytokines were measured in the sera collected before as well as 2 and 4 h post-injection. Nlrp3^S803D/S803D and Nlrp3^+/+ (n = 7). Individual values, means and 1 SD are represented, repeated measure two-way ANOVA with Sidak’s multiple comparisons of each condition with corresponding WT control; ns, non significant; *p-value < 0.05; ****p-value < 0.0001. b Mice survival to endotoxic shock. Nlrp3^S803D/S803D (n = 11), Nlrp3^+/+ (n = 10), two-sided Mantel-Cox test, **p-value < 0.01. Data are biological replicates of one experiment.