Table 3.
Comparison of immunological marker and inflammation parameter levels before and after treatment in DM patients and comparison of the immunological marker and inflammation parameter levels before and after treatment in patients without DM
| Immunological markers and inflammation parameter levels |
DM+ | DM– | |||||
|---|---|---|---|---|---|---|---|
| Before treatment | After treatment | P value | Before treatment | After treatment | P value | ||
| CD3+, CD4+ T cells% | 35.59 ± 13.46 | 33.99 ± 15.98 | 0.638 | 27.41 ± 10.78 | 35.43 ± 8.93 | 0.002 | |
| CD4+, PD1+, CXCR5+ T cells% (Tfh) | 2.81 ± 0.91 | 2.47 ± 1.20 | 0.245 | 2.50 ± 0.98 | 2.65 ± 2.66 | 0.453 | |
| CD4+, CXCR3+ T cells% (Th1) | 28.20 ± 14.92 | 26.07 ± 13.05 | 0.701 | 28.38 ± 9.10 | 24.73 ± 11.49 | 0.110 | |
| CD4+, CCR6+ T cells% (Th17) | 10.46 ± 7.63 | 12.50 ± 8.20 | 0.778 | 8.83 ± 3.85 | 9.02 ± 4.39 | 0.872 | |
| CD4+, FOXP3+ T cells% (Treg) | 4.92 ± 2.02 | 5.36 ± 2.33 | 0.530 | 5.95 ± 2.77 | 5.66 ± 1.80 | 0.576 | |
| CD4+, CD25+ T cells% (Treg) | 5.67 ± 2.38 | 5.79 ± 2.18 | 0.925 | 6.21 ± 2.99 | 5.54 ± 2.00 | 0.354 | |
| CD4+, IFN-γ+ T cells% (Th1) | 20.33 ± 19.33 | 20.94 ± 17.50 | 0.807 | 24.40 ±18.76 | 19.63 ± 13.90 | 0.258 | |
| CD4+, IL-17A+ T cells% (Th17) | 5.67 ± 6.58 | 6.02 ± 4.32 | 0.510 | 4.25 ± 4.01 | 5.67 ± 2.34 | 0.037 | |
| CD4+, IL-4+ T cells% (Th2) | 3.15 ± 2.03 | 3.75 ± 3.11 | 0.754 | 4.97 ± 4.16 | 3.26 ± 2.55 | 0.148 | |
| ESR (mm/hr) | 20.31 ± 10.16 | 9.50 ± 6.50 | 0.002 | 19.11 ± 12.43 | 10.00 ± 8.48 | < 0.001 | |
| CRP (mg/L) | 11.20 ± 8.55 | 4.13 ± 4.44 | 0.001 | 6.95 ± 9.52 | 2.39 ± 2.98 | < 0.001 | |
| NRS | 8.84 ± 0.86 | 3.28 ± 0.72 | 0.001 | 8.11 ± 0.90 | 3.50 ± 0.90 | < 0.001 | |
Values are presented as mean ± standard deviation.
DM: diabetes mellitus, Tfh: T follicular helper cells, ESR: erythrocyte sedimentation rate, CRP: C-reactive protein, NRS: numeric rating scale.