Table 3.

Histologic evaluation of epineurial fibrosis in dorsal root ganglion

Group	Grade 0	Grade 1	Grade 2	Grade 3	Grade 4
Vehicle (n = 10)	1 (10.0)	1 (10.0)	0	6 (60.0)	2 (20.0)
Sham (n = 9)	9 (100.0)	0	0	0	0
Epidural PDRN 5 mg/kg (n = 9)a	8 (88.9)	1 (11.1)	0	0	0
Epidural PDRN 10 mg/kg (n = 8)a	8 (100.0)	0	0	0	0

The values are presented as the number of animals (%).

Epineurial fibrosis, grade 0: absence, grade 1: loose and focal (< 50%) fibrosis, grade 2: loose and diffuse (> 50%) fibrosis, grade 3: dense and focal fibrosis, grade 4: dense and diffuse fibrosis.

PDRN: polydeoxyribonucleotide.

Statistical significance corrected for the secondary outcomes by the Bonferroni-correction to adjust for increased type I error by multiple comparisons (P < 0.05/2 = 0.025). ^aP < 0.025 compared to the vehicle group.