TABLE 2.
Mechanism underlying the function of SNHG14 in various cancers.
| Cancer types | Assessed cell lines | Function | Molecular mechanism | Target genes and related signal pathway | References |
| Bladder cancer (BCa) | BCa cell lines (T24, 5637, UMUC-3, and EJ) and normal bladder epithelial cells SV-HVC-1 | Invasion, migration, and proliferation | Sponging miR-211-3p | ESM1 | Feng et al., 2021 |
| Normal bladder transitional epithelial cell line SV-HUC1 and BCa cell lines T24, UC9, PAL19, and UC19 | Proliferation | Sponging miR-150-5p | VAMP2 | Li et al., 2019 | |
| Non-small cell lung cancer (NSCLC) | NSCLC cells A549, NCI-H1975, NCI-H1299, SK-MES-1, and normal human bronchial epithelial 16HBE cells | Proliferation | Sponging miR-340 | Not studied | Zhang et al., 2019d |
| Bronchial epithelioid cell line 16HBE and two NSCLC cell lines A549 and H1299 | Cisplatin resistance | Sponging miR-34a | HMGB1 | Jiao et al., 2019 | |
| NSCLC cell line PC9, gefitinib-resistant PC9 cell line (PC9/GR) | Gefitinib resistance | Sponging miR-206-3p | Not studied | Wu et al., 2019 | |
| Normal bronchial epithelial 16HBE cells and two NSCLC cell lines (A549 and SK-MES-1) | Proliferation, invasion, and migration | Sponge for miR-206 | Not studied | Zhao et al., 2020 | |
| NSCLC cell (A549) and DDP-resistant NSCLC cell (A549/DDP) | Cisplatin resistance | Sponging miR-133a | HOXB13 | Xu L. et al., 2020 | |
| H1299 and A549 cells compared with that in normal lung cell BEAS-2B | Migration, invasion, and apoptosis | Sponging miR-382-5p | SPIN1 | Chen et al., 2020 | |
| Hepatocellular carcinoma (HCC) | HCC cell lines (Hep3B and Huh-7) and normal liver cell line L02 | Proliferation and apoptosis | Sponging miR-4673 | SOCS1 | Pu et al., 2019 |
| Liver epithelial cell line (THLE-2) and the HCC cell line (Huh-7, Hep3B) | Cell proliferation and apoptosis | Sponging miR-217-5p | MAPK/ERK signaling | Xu X. et al., 2020 | |
| HCC cells (HepG2, Hep3B, MHCC-97H, and Huh-7) and human hepatocyte cells (LO2) | Proliferation, invasion, and migration | Sponging miR-656-3p | SIRT5 | Tang and Yang, 2020 | |
| Human hepatic cell line L02 cells, human HCC cell lines Hep3B, SMMC7721, Huh7, HepG2, and MHCC-97H cells | Proliferation, migration, and angiogenesis | Regulating PABPC1 | PTEN signaling pathway | Zhang H. et al., 2020 | |
| Human hepatic cell line L02 cells and human HCC cell lines HepG2, Hep3B, HLF, MHCC-97H | Proliferation, migration, and invasion | Sponging miR-876-5p | SSR2 | Liao et al., 2021 | |
| Osteosarcoma | 143B, MG-63, Saos-2, HOS, and U2OS cell lines and normal human osteoblastic cell line (HFOB1.19) | Proliferation, migration, and invasion | Sponging miR-433-3p | FBXO22 | Hou and Mao, 2020 |
| Ovarian cancer | Normal cell line HOSEpiC and ovarian cancer cell lines including C13K, SKOV3, 3AO, and OVCAR3 | Proliferation and cell cycle progression | Sponging miR-125a-5p | DHX33 | Zhao and Huang, 2019 |
| A2780, TO-V112D, HO-8910, OVCAR-3, and SKOV3 and one normal ovarian cells (ISOE80) | Migration and invasion | Regulating DGCR8 | DGCR8 | Zhao J. L. et al., 2019 | |
| Glioma | Glioma cell lines U251 and U87 and normal brain glial cell line HEB | Invasion, and apoptosis | Sponging miR-92a-3p | Not studied | Wang Q. et al., 2018 |
| Prostate cancer | Normal human myofibroblast stromal cell (WPMY1) and human prostate cancer cell lines, including LNCaP, 22RV1, PC-3, and DU145 | Not studied | Sponging miR-5590-3p | YY1 | Luo et al., 2020 |
| Breast cancer | Breast cancer cell lines SKBR-3 and BT474 | Trastuzumab resistance, proliferation, and invasion | Regulating expression PABPC1 | Not studied | Dong et al., 2018b |
| Clear cell renal cell carcinoma (ccRCC) | Human ccRCC cell lines A-498, 786-O, Caki-2, and Caki-1 and human normal renal epithelial cell line HK-2 | Migration and invasion | Regulating N-WASP | Not studied | Liu et al., 2017 |
| Retinoblastoma (RB) | Three RB cell lines Y79, SO-RB50, and Weri-RB-1 and normal retinal pigmented epithelial ARPE-19 cell line | Proliferation, migration and invasion, and apoptosis | Sponging miR-124 | STAT3 | Sun et al., 2020 |
| Diffuse large B cell lymphoma | Lymphoblastoid B cell (GM12878), human renal epithelial cell (293T), murine DLBCL cell (A20), and DLBCL cells (OCI-LY7, DB, U2932, and FARAGE) | Proliferation, migration and epithelial-mesenchymal transition | Sponging miR-5590-3p | ZEB1 | Zhao L. et al., 2019 |
| Lymphoblastoid B cell (GM12878), germinal center B cell (GCB)-like cell line (OCI-LY-7), and activated B cell (ABC)-subtype cell line (OCI-LY-3 and RCK-8) | Proliferation, apoptosis, and migration | Sponging miR-152-3p | Not studied | Tian et al., 2021 | |
| Acute myeloid leukemia (AML) | Human normal bone marrow CD34+ cells and AML cell lines (MV-4–11, AML-193, HL-60, and KG-1 cells) | Proliferation and apoptosis | Sponging miR-193b-3p/MCL1 | Not studied | Wang et al., 2021a |
| Pancreatic cancer | Pancreatic cancer cell line (SW1990), normal pancreatic cell line (HPDE6C7), and the human embryonic kidney 293T cell line | Proliferation, migration, and invasion | Sponging miR-101 | Not studied | Zhang et al., 2019b |
| Normal immortalized human pancreatic epithelial cell line (HPDE6C7) and four human pancreatic cancer cell lines (CFPAC-1, BXPC3, L3.6pl, and Panc-1) | Proliferative, invasive potentials, and apoptosis | Sponging miR-613 | Annexin A2 | Deng et al., 2019 | |
| Pancreatic ductal adenocarcinoma | Panc1, Panc28, AsPC1, and BxPC3 and a human pancreatic ductal epithelial cell line HPDE | Proliferation and invasion ability | Interacting with EZH2 | Not studied | Xie et al., 2020 |
| Colorectal cancer (CRC) | Normal human colorectal cell line NCM460 and five CRC cell lines (LoVo, SW620, SW480, HCT116, and HT-29) | Proliferation, motility, and epithelial–mesenchymal transition | Interacting with EZH2 | EPHA7 | Di et al., 2019 |
| Normal human colon epithelial cells (FHC) and other five human CRC cancer cells (Caco-2, HT-29, HCT-116, SW480, a nd SW62) | Cell growth, migration, invasion, and apoptosis | Sponging miR-92b-3p | Not studied | Zhang W. et al., 2020 | |
| CRC cell lines (SW620 and SW480), a normal human colon mucosal epithelial cell line (NCM460), and the human embryonic kidney (HEK) 293 T cell line | Cisplatin resistance, proliferation, migration, and invasion | Sponging miR-186 | ATG14 | Han et al., 2020 | |
| CRC cell lines SW620, HCT116 cells, and human normal epithelial colonic cells NCM460 | Proliferation, migration, invasion, and apoptosis | Sponging miR-944 | KRAS/PI3K/AKT pathway | Pei et al., 2019 | |
| CRC cell lines (LoVo, RKO, SW480, and HT-29) and normal colon epithelial cells (NCM460) | Proliferation, metastasis, and epithelial-mesenchymal transition process | Sponging miR-32-5p | SKIL | Ye et al., 2019 | |
| Sponging miR-519b-3p | DDX5 | Wang et al., 2021b | |||
| Human CRC cell lines (SW480, HT-29, HCT-8 and DLD-1) and human normal colon epithelial cells (NCM460) | Proliferation, migration, invasion, and apoptosis | ||||
| Cervical cancer (CC) | CC cell lines (SiHa, HeLa, C33a, Me180, and Ms751) and human normal cervical cell lines (Ect1/E6E7) | Proliferation, migration, invasion, and apoptosis | Sponging miR-206 | YWHAZ | Ji et al., 2019 |
| CC cell lines (SW756, SiHa, and HeLa) and normal endo-cervical epithelial cell line (End1/E6E7) | Proliferation and apoptosis | JAK-STAT pathway | Zhang et al., 2019c | ||
| Endometrial cancer (EC) | Human EC cell lines (HEC-1A, HEC-1B, KLE, and Ishikawa) and human endometrial stromal cell line (T-HESC) | Cell proliferation and apoptosis | Sponging miR-655-3P | Not studied | Zhao et al., 2020 |
| Human embryonic stem cell and EC cell lines (HEC1-A, HEC1-B, AN3CA, and Ishikawa) | Viability, migration, and invasion | Sponging miR-93-5p | Not studied | Zhang K. et al., 2020 |