Figure 4.
The correlation between HNRNPA2B1 and clinicopathologic parameters of OSCC. (A–C) Rank chart for the 19 m6A regulatory genes by neural network, random forest (rf), and gradient boosting machine (gbm). (D) HNRNPA2B1 expression is higher in tumor tissues compared with normal tissues. High HNRNPA2B1 expression was significantly associated with (E) tumor stage, (F) T categories, and (G) metastasis. (H) HNRNPA2B1 expression was not associated with histological grade (p > 0.05). (I) The mRNA expression of HNRNPA2B1 in patients with or without lymph node metastasis was detected by RT-PCR. (J) Representative images of immunohistochemical staining and (K) quantification of HNRNPA2B1 in human normal mucosa, OSCC tissue, and metastasis LN. Metastasis means at least one lymph node metastasis, local or distant metastasis. (L) LINE-1 expression is positively correlated with HNRNPA2B1 expression according to the analysis results of the IHC score. * and **** indicated p<0.05 and p<0.0001, respectively. “ns” indicates no significance.