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. 2021 Sep 23;12:717688. doi: 10.3389/fimmu.2021.717688

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Copyright © 2021 Song, Zheng, Wu, Wang, Meng, Yao, Li and Lian

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PTP4A3 expression associates with low CD3+/CD8+ infiltration in renal cancers. (A) Representative IHC stain in 10 renal tumor tissues. PTP4A3 negative stains (upper panel) and positive stains (lower panel) with CD3+ intratumor stains, CD3+ invasion margins stains, CD8+ intratumor stains, CD8+ invasion margins stains, 20× magnification, scale bar, 50μM. (B) CD3+/CD8+ infiltration in tumor center (intratumor) and invasion margins in the PTP4A3 negative and positive tissues. All data were manually counted of positive cells in 4 HPF in each tumor field. (C) Histogram of the CD3+ and CD8+ intratumor and invasion margins infiltrations in renal cancers. All data are mean ± SE.