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Butyrate treatment reversed the high sympathetic tone after myocardial I/R, and vagotomy diminished this protective effect. (A) LF, (B) HF, and (C) LF/HF. (D) Serum NE. ****p < 0.0001 vs. sham group; ##p < 0.01, ####p < 0.0001 vs. I/R group; &&&&p < 0.0001 vs. butyrate group. LF, low frequency; HF, high frequency; NE, norepinephrine; I/R, ischemia/reperfusion.
