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. 2021 Sep 23;9:727286. doi: 10.3389/fcell.2021.727286

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Copyright © 2021 Chen, Guo, Jia, Wan, He, Fang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Correlation plot depicting top 50 loading genes and top 20 loading species correlations based on Spearman analysis (*** indicates p-value < 0.001, ** indicates p-value < 0.01, and * indicates p-value < 0.05). (B) Network visualizing the relationship between species, genes, and pathways. The solid line indicates the positive correlation (red) or negative (blue) relationship between the species and the gene. The dotted line indicates the positive correlation (red) or negative (blue) relationship between the species. Functional enrichment analysis of Pannonibacter phragmitetus (C) and Anaerostipes hadrus (D).