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. 2021 Sep 23;11:654202. doi: 10.3389/fcimb.2021.654202

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Copyright © 2021 Hao, Li, Wu and Tan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Shows the differential abundance and association analysis among the cervical microbiota of the fresh pregnancy group and the non-pregnancy group. (A) LEfSe analysis chart: The LDA score of the genera which showed differentially abundance between pregnant and non-pregnant women in fresh IVF-ET cycle. (B) Spearman correlation coefficient analysis: the important patterns and relationships among the genera abundance with Top 30 in FP, FN groups (C) Spearman thermal map analysis of the correlation between the serum sex hormone levels and genera which were detected in LEfSe analysis. FN, fresh IVF-ET cycle non-pregnancy; FP, fresh IVF-ET cycle pregnancy. E₂, estradiol; LDA, Linear discriminant analysis; LEfSe, Linear discriminant analysis effect size analysis; P, progesterone. ⁺ P < 0.05; *P < 0.01.