Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Sep 25;3(4):fcab223. doi: 10.1093/braincomms/fcab223

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Oligomeric ɑ-syn forms detected in 100-day old hMOs. (A) Syn-PLA on positive control paraffin sections, SN of patient with DLB, showing oligomeric α-syn forms (Syn-PLA), α-syn (α-syn), and pS129Syn in LNs (arrow) and LBs (triangles). (B) Syn-PLA on paraffin sections showed the highest quantity of α-syn oligomers (Syn-PLA), α-syn (ɑ-syn) and pS129Syn signal in SNCA Tri hMOs. Scale bar = 40 μm. (C) Quantification of Syn-PLA signal normalized to nuclei staining (n = 9, mean ± SEM, Kruskal–Wallis test, followed by Dunn’s multiple comparisons test, *P-value = 0.0282, **P-value = 0.0015).