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. 2021 Sep 23;12:758219. doi: 10.3389/fphar.2021.758219

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Copyright © 2021 Chang, Zhu, Chen, Zhang, Liu, Li, Cheng, Su, Zhang, Lu and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TFLS inhibited the metastasis of PCa cells. (A) The effects of TFLS on the migration of PC3 and DU145 cells were analyzed using wound-healing assay. (B,C) Quantitative analysis of average wound healing degrees of PC3 and DU145 cells. (D) Invasiveness of PC3 and DU145 cells that underwent TFLS treatment determined by transwell invasion assay. (E,F) Invaded PC3 and DU145 cells were quantified; Data are expressed as mean ± SEM, compared with the control group: *p < 0.05; **p < 0.01.