TABLE 3.
Electrophysiological properties of Kv1.3 channels, in patients with multiple sclerosis (MS) (n = 38) and control groups (n = 52). Data are presented as means ± SEM. (tn: activation time constant; tj: inactivation time constant; Vn: potential of half-maximal activation; Vj: potential of half-maximal steady-state inactivation; Imax: peak current amplitude following depolarization to +40 mV; Cm: membrane capacitance).
| Group | Activation threshold | τn (ms) | τj (ms) | Vn (mV) | Vj (mV) | Imax (pA) | Cm (pF) | Kv1.3 channel density (channels/μm2) |
|---|---|---|---|---|---|---|---|---|
| Definite MS | −35 mV | 3.4 ± 0.4 | 169 ± 4.2 | −32.3 ± 2.5 | −53.5 ± 1.9 | 636.3 ± 29.3 | 1.67 ± 0.1 | 2.5 ± 0.04 |
| Relapsing remitting | −35 mV | 3.5 ± 0.3 | 167 ± 3.2 | −31.8 ± 2.1 | −53.1 ± 2.2 | 596.7 ± 32.2 | 1.68 ± 0.1 | 2.4 ± 0.04 |
| Secondary progressive | −35 mV | 3.4 ± 0.5 | 171 ± 5 | −32.7 ± 2.6 | −53.7 ± 2.1 | 680.5 ± 28.4 | 1.65 ± 0.2 | 2.7 ± 0.05 |
| CIS | −35 mV | 3.5 ± 0.3 | 169 ± 4.7 | −31.9 ± 2.5 | −52.8 ± 2.3 | 432.6 ± 36.8 | 1.80 ± 0.1 | 1.8 ± 0.09 |
| OND | −35 mV | 3.6 ± 0.5 | 172 ± 5.1 | −32.3 ± 3 | −51.6 ± 1.9 | 449.2 ± 35.1 | 1.6 ± 0.2 | 1.8 ± 0.0.7 |
| OIND | −35 mV | 3.8 ± 0.4 | 173 ± 4.4 | −32 ± 2.4 | −51.9 ± 2 | 435.66 ± 31.9 | 1.68 ± 0.1 | 1.8 ± 0.1 |
| Healthy controls | −35 mV | 3.5 ± 0.3 | 171 ± 4.4 | −33.1 ± 2.6 | −53.5 ± 1.8 | 455.3 ± 29.5 | 1.65 ± 0.1 | 1.8 ± 0.05 |