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Heterogeneous cellular energy metabolism within breast cancer cells. Highly proliferating breast cancer cells rely on glycolysis to provide cellular energy. Quiescent breast cancer stem cells use more oxidative phosphorylation (OxPhos) instead of glycolysis to generate ATP. Proliferating cancer stem cells rely on both glycolysis and Oxphos. Both quiescent and proliferating cancer stem cells can use catabolites from cancer-associated stromal cells through the Reverse Warburg effect.
