FIGURE 5.

Desmosomal proteins regulate inflammatory processes during wound healing (created with biorender.com). Activated PRR signaling through intrinsic or extrinsic insults as well as upon tissue wounding induce signaling cascades affecting the amount and/or the localization of desmosomal proteins and thus cellular cohesion and proliferation. Moreover, through interfering with various signaling pathways including p38MAPK, Wnt, and Hippo signaling, desmosomal proteins are able to modulate inflammatory responses. Since most desmosomal proteins have been described to dampen inflammation, these proteins could be required to locally restrict inflammatory responses and/or ensure the resolution of inflammatory responses required for tissue regeneration.