Figure 1.

Overall study pipeline. Comparison of 144 tumor pancreatic tissue from TCGA with 180 normal pancreatic tissue from GTEx. Data for validation were considered from Jin et al. (29) with 10 PDAC samples and Fagerberg Lin et al. (30) with two replicated from two normal samples. We used the MiXCR tool to extract IG and TCR from RNA sequencing data and then performed a detailed statistical study to characterize properly the tumor-infiltrating immune repertoire by applying diversity, network, association, and clonotype analyses.