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. 2021 Sep 23;12:713322. doi: 10.3389/fphar.2021.713322

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Copyright © 2021 Hou, Xia, Feng, Cui, Yang, Yang and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulation of Bax transcription by TCEA3. (A) USP47 and Bax expressions were correlated. Data were retrieved from GEPIA database. (B) Bax mRNA level in HCT116 cells was increased after the transfection of USP47-targeted siRNAs for 24 h **p < 0.01, ***p < 0.001. (C) The mRNA level of Bax was reduced in HCT116 cells after the transfected of TCEA3-expressing plasmid for 24 h **p < 0.01, ***p < 0.001. (D) Bax was increased in HCT116 cells following transfection with TCEA3-targeted siRNAs for 48 h as examined by anti-Bax immunoblotting. (E) The expression of Bax in HCT116 cells transfected with TCEA3-expressing plasmid and/or USP47-targeted siRNAs for 48 h.