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. 2021 Sep 23;11:686294. doi: 10.3389/fonc.2021.686294

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Copyright © 2021 Shi, Wu, Wang, Liu, Wang, Luo, Su, Zhai and Tian

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Serum from RFA patients receiving GA facilitated cell proliferation of HepG2 cells after long-term, but not short-term, exposure. (A) CCK-8 assay OD values (culture time = 24h); (B) CCK-8 assay OD values (culture time = 48h); (C) mean percentage change from post- to preoperative OD value (culture time = 24h); (D) mean percentage change from post- to preoperative OD value (culture time = 48h). Values are expressed as mean ± SD. n = 11, LA group. n = 13~14, GA group. **P < 0.01. GA, General Anesthesia; LA, Local Anesthesia.