TABLE 3.
Race and other demographic factors associated with neutropenia among all taxane patients
|
Mild (Grade 2) (N = 455) |
Moderate (Grade 3) (N = 396) |
Severe (Grade 4) (N = 323) |
|||||
|---|---|---|---|---|---|---|---|
| N a | OR (95% CI) b | N | OR (95% CI) | N | OR (95% CI) | ||
| Race | |||||||
| White | 387 / 2224 | Reference | 322 / 2159 | Reference | 277 / 2114 | Reference | |
| Black | 57 / 253 | 1.53 (1.09–2.14) | 62 / 258 | 1.91 (1.36–2.67) | 35 / 231 | 1.19 (0.79–1.79) | |
| Other | 11 / 81 | 0.74 (0.38–1.44) | 12 / 82 | 1.02 (0.53–1.94) | 11 / 81 | 1.09 (0.55–2.17) | |
| Age | |||||||
| <55 | 154 / 853 | Reference | 138 / 837 | Reference | 100 / 799 | Reference | |
| 55 to <65 | 133 / 804 | 0.89 (0.67–1.18) | 113 / 784 | 0.81 (0.60–1.09) | 88 / 759 | 0.93 (0.67–1.30) | |
| 65 to <75 | 123 / 659 | 1.16 (0.86–1.55) | 98 / 634 | 0.94 (0.69–1.29) | 93 / 629 | 1.12 (0.80–1.57) | |
| ≥75 | 45 / 242 | 1.08 (0.72–1.63) | 47 / 244 | 1.19 (0.79–1.79) | 42 / 239 | 1.23 (0.79–1.91) | |
| Sex | |||||||
| Female | 281 / 1482 | Reference | 245 / 1446 | Reference | 192 / 1393 | Reference | |
| Male | 174 / 1076 | 0.89 (0.65–1.23) | 151 / 1053 | 0.63 (0.46–0.86) | 131 / 1033 | 0.75 (0.53–1.06) | |
| BMI | |||||||
| 18.5 to <25 | 153 / 803 | Reference | 129 / 779 | Reference | 100 / 750 | Reference | |
| <18.5 | 13 / 75 | 0.81 (0.39–1.69) | 17 / 79 | 1.30 (0.68–2.48) | 14 / 76 | 1.80 (0.91–3.57) | |
| 25 to <30 | 153 / 817 | 0.96 (0.73–1.25) | 112 / 776 | 0.90 (0.67–1.21) | 108 / 772 | 1.12 (0.82–1.53) | |
| 30 to <35 | 121 / 724 | 0.83 (0.63–1.10) | 116 / 719 | 0.99 (0.74–1.33) | 78 / 681 | 0.88 (0.63–1.24) | |
| ≥40 | 15 / 139 | 0.42 (0.23–0.76) | 22 / 146 | 0.69 (0.41–1.18) | 23 / 147 | 1.01 (0.59–1.72) | |
| Ever smoke | |||||||
| No | 223 / 1220 | Reference | 200 / 1197 | Reference | 161 / 1158 | Reference | |
| Yes | 208 / 1166 | 1.02 (0.80–1.30) | 177 / 1135 | 0.87 (0.67–1.12) | 151 / 1109 | 0.85 (0.65–1.13) | |
a
Reporting as counts of patients in category / sum of patients with no neutropenia and patients in category.
b
All variables included in the multinomial analysis with adjustments for mean treatment dose, number of treatment cycles, and base neutrophil count, prior platinum treatment, prior radiotherapy, cancer site, and all other variables included in the table.