TABLE 3.
Urinary biomarkers values normalized for urinary creatinine according to presence of acute kidney injury in patients hospitalized in wards and receiving vancomycin.
| Urinary biomarker/creatinine (mg/dl/mg/dl) | Non-AKI n = 71 | AKI n = 23 | p |
|---|---|---|---|
| IL-18 (x 10–7)/cr | |||
| 1 (até 48 h) | 4.56 ± 2.067 | 7.12 ± 1.28 | 0.25 |
| 2 (48–96 h) | 4.95 ± 2.42 | 5.34 ± 1.81 | 0.84 |
| 3 (96–144 h) | 8.92 ± 4.188 | 5.46 ± 2.43 | 0.68 |
| 4 (144–192 h) | 2.44 ± 1.73 | 10.18 ± 6.56 | 0.03 |
| KIM-1 (x 10–7)/cr | |||
| 1 (até 48 h) | 33.68 ± 7.90 | 38.40 ± 4.24 | 0.62 |
| 2 (48–96 h) | 37.30 ± 6.94 | 42.18 ± 6.31 | 0.74 |
| 3 (96–144 h) | 37.08 ± 6.49 | 49.32 ± 6.01 | 0.33 |
| 4 (144–192 h) | 29.24 ± 8.98 | 49.91 ± 8.20 | 0.29 |
| NGAL (x 10–7)/cr | |||
| 1 (até 48 h) | 69.484 ± 13.19 | 210.94 ± 35.86 | 0.05 |
| 2 (48–96 h) | 181.67 ± 63.84 | 225.67 ± 44.60 | 0.008 |
| 3 (96–144 h) | 191.28 ± 50.19 | 272.29 ± 44.86 | 0.55 |
| 4 (144–192 h) | 36.18 ± 9.31 | 398.17 ± 87.13 | 0.05 |
| TIMP-2 x IGFBP/cr | |||
| 1 (até 48 h) | 48.11 ± 11.65 | 43.11 ± 29.13 | 0.76 |
| 2 (48–96 h) | 49.21 ± 17.43 | 53.14 ± 31.42 | 0.84 |
| 3 (96–144 h) | 51.17 ± 19.23 | 66.76 ± 41.41 | 0.69 |
| 4 (144–192 h) | 58.16 ± 25.12 | 282.52 ± 66.25 | 0.25 |
IL-18, interleukin 18; KIM-1, kidney injury molecule-1; NGAL, neutrophil gelatinase-associated lipocalin; TIMP-2, tissue inhibitor of metalloproteinases 2; IGFBP-7, insulin-like growth factor binding protein 7