Figure 4.

MSLN-CAR NK cells showed antitumor activity in subcutaneous gastric cancer mouse model. A. Schematic representation of the experiment. NSG mice received a subcutaneous injection of 2×10⁶ N87 cells. When tumor volume reached about 50 mm³, 5×10⁶ CAR NK cells were injected every seven days through the tail vein and tumor volume was measured every four days. B. Tumors dissected from different groups at the end point. C. Tumor volume curves of N87 subcutaneously injected mice. D. Tumor weight in each group at the end point. E. Histopathological analysis of murine organ tissues by hematoxylin and eosin (H&E) staining. Representative staining image fields (magnification × 200) are shown. Scale bar represented 100 µm. Error bars denoted the SD. *P<0.05, **P<0.01, ***P<0.001.