Figure 5.

MSLN-CAR NK cells showed strong antitumor activity in vivo in an i.p. gastric cancer model. A, Schematic representation of the experiment. B, BLI of MKN-28 GL intraperitoneally injected mice treated with CAR NK cells (i.p.). On day 0, NSG mice received an i.p. injection of 1 × 10⁶ MKN-28 GL cells. After 10 days, 5×10⁶ CAR NK cells were routinely injected intraperitoneally at the indicated time. On day 10, 15, and 30, BLI was performed. C, Statistical analysis of the ROI of each BLI at each time point. Error bars denote the SD, and the results were compared with two-way ANOVA test. D, Survival curve of MKN-28 GL intraperitoneally injected mice. The results were performed with Log-rank (Mantel-Cox) test. *P<0.05, **P<0.01, ***P<0.001.