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. 2021 Sep 3;17(14):3850–3861. doi: 10.7150/ijbs.64630

Figure 6.

Figure 6

MSLN-CAR NK cells efficiently inhibit growth of patient-derived xenografts (PDXs) of gastric cancer. A. MSLN expression in PDX1, PDX2, and PDX3 by IHC (200×), scale bar: 100 µm. B. Tumor volume curves after regularly administration with CAR NK cells or PBS (black arrow). C-D. At the end of the experiment, the tumors treated with MSLN-CAR NK cells were significantly smaller and lighter than those in the NC and CD19-CAR NK groups. E. Representative tumor sections stained with CD56 were shown. The specimens were harvested from PDXs sacrificed after the study was terminated. Nuclei are stained with hematoxylin (200×), scale bar: 100 µm. F. Infiltration percentages of MSLN- or CD19-CAR NK cells in tumors were detected by flow cytometry. Data were presented as the mean ± SD. *p < 0.05, **p < 0.01, and ***p < 0.001.