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. 2021 Aug 28;17(14):3760–3775. doi: 10.7150/ijbs.61717

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A, B. QuSAGE Gene Enrichment Analysis revealed enriched biological processes (A) and KEGG pathways (B) for specific genes of each malignant subcluster. C. Heatmap of SCENIC analysis, showing the relative activity of transcription factors in each malignant subcluster at single-cell level. The blue box highlights the prominent transcription factors with high activity specific to subcluster 6. D. Violin plots displaying the expression of E2F3, E2F1, and E2F7 across the seven malignant subclusters. E. Violin plots displaying the expression of EZH2 and SP3 across the seven malignant subclusters. F. Heatmap showing the expression levels of drug-metabolism genes in each malignant subcluster. G. A violin plot showing the expression of DHFR in each malignant subcluster. H. Heatmap showing the expression levels of drug-resistance genes in each malignant subclusters. I. Violin plots showing the expression of TOP2A, BCL2, and BAX in each malignant subcluster.