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. 2021 Sep 7;17(14):3875–3888. doi: 10.7150/ijbs.62517

Figure 4.

Figure 4

MELK is associated with mitosis in cervical cancer cells. A. HeLa cells were treated with DMSO or 5μM MELK-8A for 24 h. Mitotic spindles and DNA were visualized by immunofluorescent staining for α-tubulin and by staining with DAPI, respectively. DMSO was used as a control. Scale bars correspond to 25 µm. B. Expression of MELK in the cell G2/M phase from the Cyclebase3.0 cell cycle database. C. HeLa cells were treated with DMSO or 5 µM MELK-8A for 48h and 72h. Mitotic spindles and DNA were visualized by immunofluorescent staining for α-tubulin and by staining with DAPI, respectively. For MELK-8A-treated cells, normal mitotic phases were not found. DMSO was used as a control. Scale bars correspond to 20 µm.