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Pae protects against DDPIN through regulating lnc-MEG3 /miRNA-126/mTOR-mediated autophagy. Relative mRNA level of lnc-MEG3 (A) and (B) miRNA-126 in DDP or/and Pae-treated (15 mg/kg and 30 mg/kg) mice. (C and D) Western blot analysis of p-AKT, AKT, TSC2, TSC1, TBC1D7, p-mTOR, mTOR, Atg5, Beclin-1 and LC3 in the DDP or/and Pae-treated (15 mg/kg and 30 mg/kg) mice. *P < 0.05, **P < 0.01, ***P < 0.001 versus control, #P < 0.05, ##P < 0.01, ###P < 0.001 versus DDP-treated control (n=3).
