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Schematic representation of the ASK1/MKK7/JNK1 pathway in BCL-2 phosphorylation. ASK1, a MAP3K, is activated by extracellular and intracellular stimuli to induce JNK pathway activation. JNK phosphorylates BCL-2, inactivating its antiapoptotic function. TNFR1, tumor necrosis factor receptor 1.
