Table 3.
Morphological and biochemical changes in mice with different Lrp6 genotypes under different treatments
| Parameters | Lrp6(+/+) genotype | Lrp6(+/-) genotype | ||||
|---|---|---|---|---|---|---|
| MCS | MCD | MCD+Silibinin | MCS | MCD | MCD+Silibinin | |
| Liver body ratio (%) | 3.87±0.16 | 5.71±0.76*** | 4.62±0.69# | 3.91±0.19 | 5.28±0.32*** | 4.70±0.54 |
| ALT (U/L) | 28.25±4.99 | 411.57±59.30*** | 306.43±27.82# | 37.70±19.85 | 323.58±43.15*** | 272.36±16.73# |
| AST (U/L) | 124.35±44.45 | 466.68±81.96*** | 342.23±43.18# | 150.05±19.87 | 308.15±32.93*** | 253.98±36.43 |
| LDL (mmol/L) | 0.60±0.05 | 0.12±0.03*** | 0.17±0.02# | 0.50±0.13 | 0.17±0.03*** | 0.19±0.03 |
| MDA (μmol/g protein) | 0.52±0.11 | 1.96±0.20*** | 1.22±0.57 | 0.48±0.04 | 1.43±0.14*** | 1.19±0.19 |
| TG (mmol/g protein) | 0.21±0.05 | 0.34±0.03*** | 0.27±0.06 | 0.22±0.05 | 0.33±0.06* | 0.29±0.02 |
| TC (mmol/g protein) | 27.28±8.48 | 55.54±3.04*** | 35.09±18.11 | 22.80±10.34 | 42.03±2.78** | 34.73±3.36 |
Note: MCS, the mice were fed with methionine- and cystine supplement diet; MCD, the mice were fed with methionine-choline deficient diet; MCD+Silibinin, the mice were coadministrated with 100mg/kg/d silibinin by intragastric during MCD feed;
Abbreviations: ALT, alanine transaminase; AST, aspartate aminotransferase; LDL, low-density lipoprotein; MDA, malondialdehyde; TG, triglyceride; TC, total cholesterol.
* P<0.05; ** P<0.01; ** P<0.001; Statistic analysis were performed between MCS and MCD groups.
# P<0.05; Statistic analysis were performed between MCD and MCD+Silibinin groups.