Fig. 2.

Applications of baculoviruses. Illustrations indicating the main uses of baculoviruses. A Because of the research and development carried out on the biology of baculoviruses, 3 main applications have been generated: bioinsecticides, baculovirus expression vector systems (BEVS), and baculoviruses applied to mammals (BacMam). B Main procedures for the generation of bioinsecticide products based on occlusion bodies (OBs). C Main procedures for the generation of protein products based on recombinant budded viruses (recBVs) infecting insect cells and subsequent downstream processes. D. Main procedures for the generation of virion products based on recBVs infecting insect cells and subsequent downstream processes. Only 3 alternatives of recBVs are illustrated: virions that display proteins in the envelope; virions that carry transgenes for the expression in mammal cells; virions that display proteins in the nucleocapsid