Thrombin generation *	Y‐Sh	Y‐AF	O‐Sh	O‐AF	ANOVA (all groups)	Tukey's post hoc
						Y‐Sh vs. Y‐AF	Y‐Sh vs. O‐Sh	O‐Sh vs. O‐AF	Y‐AF vs. O‐AF
Peak height (nM) ‐ baseline	157 ± 50	175 ± 43	155 ± 54	175 ± 52	ns	ns	ns	ns	ns
Peak height (nM) ‐ final	179 ± 55	199 ± 45	145 ± 17	220 ± 52**	ns	ns	ns	ns	ns
Atrial histology
LA myocyte size (μm)	12.1 ± 1.5	11.7 ± 0.9	12.3 ± 1.0	13.4 ± 0.8	P < 0.05	ns	ns	*	ns
RA myocyte size (μm)	11.2 ± 1.1	11.2 ± 0.8	11.9 ± 0.8	12.6 ± 1.0	P < 0.05	ns	ns	*	ns
LA endomysial fibrosis (μm)	5.8 ± 0.3	5.8 ± 0.6	5.6 ± 0.3	6.0 ± 0.4	ns	ns	ns	ns	ns
RA endomysial fibrosis (μm)	6.2 ± 0.3	6.0 ± 0.3	6.0 ± 0.6	6.2 ± 0.5	ns	ns	ns	ns	Ns

*Thrombin generation; Peak height baseline vs. final (paired t‐test): O‐AF P < 0.01** (n = 7). All values mean ± SD.