Q1 0.01‐0.27 µg/ml	Q2 0.27‐0.39 µg/ml	Q3 0.39‐0.61 µg/ml	Q4 0.61‐20.1 µg/ml	P‐value for trend*
All 434 cases/3235 at risk
Model 1	1.0	1.06 (0.82, 1.38)	0.84 (0.64, 1.11)	1.01 (0.77, 1.32)	0.6
Model 2	1.0	0.96 (0.74, 1.24)	0.74 (0.56, 0.97)	0.79 (0.61, 1.04)	0.03
Women 205 cases/1632 at risk
Model 1	1.0	1.11 (0.74, 1.66)	0.86 (0.57, 1.29)	1.25 (0.85, 1.82)	0.5
Model 2	1.0	0.98 (0.65, 1.47)	0.76 (0.51, 1.13)	0.95 (0.66, 1.38)	0.5
Men 229 cases/1603 at risk
Model 1	1.0	1.04 (0.74, 1.47)	0.85 (0.57, 1.25)	0.70 (0.47, 1.06)	0.06
Model 2	1.0	0.94 (0.67, 1.32)	0.69 (0.47, 1.01)	0.57 (0.38, 0.85)	0.002

Model 1: age, gender, race, education and income; model 2: model 1+ smoking, alcohol use, physical activity, BMI, systolic blood pressure, total cholesterol and C‐reactive protein

The P‐values of the interaction D‐dimer*race were >0.1

The P‐values of the interaction D‐dimer*race were ≤ 0.05

^*P‐value for trend across quartiles of D‐dimer

Q: quartile