2001	2002	2006	April 2020	August 2020	February 2021
Hemoglobin 11.7–16 mg/dL		12.5	12.8	12.8	11.5	12.7
Platelet count (150–450 x103 cells/µL)		142 199	244	172 149 131	38 43 55	174
Protein C activity (70–130%)		58%	89%
Protein S activity (62–163%)		60%	55%
Protein S Ag free (70–160%)			60%
ADAMTS13 activity					< 5%; 9% after 4 plasma exchanges	5
Imaging studies	MRI: Subacute left basal ganglia infarct and acute left parietal lobe infarct Normal trans‐esophageal echocardiogram	MRI: old left parietal, left caudate, and right frontal (subcortical/parasagittal) infarcts		MRI: acute infarction in the right superior frontal gyrus and subacute infarct at the right inferior frontal gyrus with hemorrhagic conversion	CT: Acute right middle cerebral infarct
Antithrombotic agent	Aspirin low‐dose	Warfarin INR target 2–3	Enoxaparin to allow for testing protein C and S	Warfarin INR 1.8 on admission	Apixaban 5 mg twice daily	Apixaban 5 mg twice daily
Other					Plasma exchange	Plasma infusions bi‐monthly