Table 5.
The within patient minimal clinically important difference.
| Anchor-based method MCID (95% CI) | Distribution-based methods | Median | ||
|---|---|---|---|---|
| 0.5 × SD (95% CI) | 1 × SEM (95% CI) | |||
| SGRQ | 3.84 (−3.24,10.94) | 9.58 (8.9,10.39) | 6.96 (3.23,3.77) | 6.96 |
| EQ-5D | 0.06 (−0.01, 0.13) | 0.11 (0.1,0.12) | 0.11 (0.05,0.06) | 0.11 |
| MRC | 0.1 (−0.47,0.26) | 0.53 (0.49,0.57) | 0.41 (0.19,0.22) | 0.41 |
| HADS | 0.89 (−1.18,2.95) | 3.68 (3.37,4.06) | 2.44 (1.12,1.35) | 2.44 |
| K-BILD | 4.1 (−0.50,8.69) | 7.01 (6.23,7.95) | 6.25 (2.78,3.55) | 6.25 |
| UCSD | 9.55 (2.97,16.14) | 14.19 (13.1,15.53) | 4.14 (3.82,4.53) | 9.55 |
| SGRQ-I | 4.31 (−4.57, 13.18) | 11.24 (10.57,12.06) | 8.88 (4.18,4.76) | 8.88 |
Minimal clinically important difference using anchor and distribution methods for EQ-5D-5 L: EQ-5D: EuroQol five dimension, FVC: forced vital capacity, HADS: hospital anxiety and depression scale, K-BILD: King’s Brief Interstitial Lung Disease Questionnaire, mMRC: Medical Research Council dyspnea score, SGRQ: St George’s Respiratory Questionnaire, SGRQ-I, St George’s Respiratory Questionnaire–interstitial lung disease, UCSD: University of California, San Diego shortness of breath questionnaire. SD: standard deviation, SEM: standard error of mean.