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. 2021 Sep 20;22(5):1318. doi: 10.3892/etm.2021.10753

Figure 6.

Figure 6

Effect of miR-18a-5p mimic on Smad2, Col I and Col III in hHSFs. The hHSFs were transfected with mimic control, miR-18a-5p mimic, or miR-18a-5p mimic + Smad2-plasmid for 48 h. (A) Western blot assay was performed to measure the protein levels of Smad2, Col I and Col III in hHSFs. (B) Smad2, (C) Col I and (D) Col III relative protein levels in hHSFs were calculated and are presented as the fold of the control levels. (E) Smad2, (F) Col I and (G) Col III mRNA levels in hHSFs were measured by reverse transcription-quantitative polymerase chain reaction. Data are presented as the mean ± standard deviation. **P<0.01 vs. control group; ##P<0.01 vs. mimic group. miR, microRNA; hHSFs, human hypertrophic scar fibroblasts; Col, Collagen.