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. 2021 Aug 30;297(4):101148. doi: 10.1016/j.jbc.2021.101148

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© 2021 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Skp2-dependent ubiquitination is responsible for premature disassembly of the MRN complex.A, immunostaining of Mre11, Nbs1, or Rad50 in mock- (siGL) or RecQL4-depleted U2OS cells treated with neocarzinostatin (NCS) and released for 1 h in the absence (−) or presence (+) of MG132 (50 μg/ml). The scale bar represents 10 μm. B, percentages of RPA foci-positive cells in mock- or RecQL4-depleted (siR4) U2OS cells after mock or NCS treatment in the absence or presence of MG132. Data in graphs are means ± SD; n = 3. C, percentages of Mre11 foci-positive cells, 1 h after NCS treatment, among cells depleted for the indicated proteins. R4, RecQL4; S2, Skp2; C34, Cdc34; U5, Ubc5; U13, Ubc13. Data in graphs are means ± SD; n = 3. ∗∗p < 0.01.