Skip to main content
. 2021 Sep 22;6(39):25652–25663. doi: 10.1021/acsomega.1c03777

Table 2. Anti-Helicobacter pylori Effect of Piper Essential Oilsa.

  inhibition %
sample conc. (μg/mL) P. longum white pepper P. cubeba P. nigrum clarithromycin
125 100 ± 0 100 ± 0 100 ± 0 100 ± 0 100 ± 0
62.5 100 ± 0 100 ± 0 100 ± 0 100 ± 0 100 ± 0
31.25 100 ± 0 100 ± 0 100 ± 0 100 ± 0 100 ± 0
15.63 100 ± 0 100 ± 0 100 ± 0 100 ± 0 100 ± 0
7.81 100 ± 0 100 ± 0 100 ± 0 100 ± 0 100 ± 0
3.9 100 ± 0 100 ± 0 89.41 ± 0.52 82.32 ± 0.83 100 ± 0
1.95 100 ± 0 84.41 ± 1.96 72.32 ± 1.30 50.37 ± 0.82 100 ± 0
0.98 91.17 ± 0.55 61.60 ± 0.73 56.73 ± 0.59 22.31 ± 0.88 91.98 ± 0.42
0.48 73.44 ± 1.45 29.97 ± 0.87 29.10 ± 0.18 9.84 ± 0.51 86.28 ± 1.27
0.24 50.74 ± 0.87 16.82 ± 1.04 12.99 ± 0.85 0 81.83 ± 0.43
0 0 0 0 0 0
MIC (μg/mL) 1.95 3.9 7.81 7.81 1.95
a

The test was done using the standard MTT assay to determine the bacterial growth. For MIC, different concentrations of the tested oils or reference antibiotic clarithromycin were prepared in DMSO (final concentration ranges in the wells were 125 to 0.24 μg/mL). Results are expressed as means ± SD of triplicate values.