Table 5.
Association Between Brain Region and Each Activity Metric Adjusted for Each Other, Mean (SD), n = 301
| Physical Activity Amount (min/day)† | Fragmentation (%/day)‡ | |
|---|---|---|
| Beta Coefficient (SE) | ||
| Total brain | 0.20 (0.09)* | −0.01 (0.005) |
| Gray matter | 0.12 (0.17) | −0.01 (0.010) |
| White matter | 0.46 (0.18)* | −0.02 (0.010) |
| Ventricles | 0.15 (0.21) | −0.003 (0.01) |
| Frontal | 0.21 (0.25) | 0.02 (0.014) |
| Gray matter | −0.07 (0.43) | −0.04 (0.025) |
| White matter | 0.57 (0.39) | −0.03 (0.023) |
| Parietal | 1.21 (0.45)** | −0.04 (0.026) |
| Gray matter | 1.20 (0.73) | −0.06 (0.042) |
| White matter | 2.02 (0.75)** | −0.06 (0.043) |
| Temporal | 1.11 (0.45)* | −0.03 (0.026) |
| Gray matter | 0.36 (0.70) | −0.04 (0.040) |
| White matter | 2.46 (0.71)** | −0.04 (0.043) |
| Occipital | −0.20 (0.51) | −0.02 (0.029) |
| Gray matter | −0.65 (0.79) | −0.03 (0.045) |
| White matter | 0.33 (1.08) | −0.06 (0.062) |
| Hippocampus | −3.27 (6.53) | −0.36 (0.375) |
| Cerebellum (n = 282) | 0.70 (0.44) | 0.003 (0.025) |
Notes: All models adjusted for intracranial volume (cc), age (years), sex, race (white vs other), education (years), body mass index (kg/m2), depression, usual gait speed (m/s), number of morbid conditions, and Apolipoprotein E4 status.
†Additionally adjusted for tertiles of fragmentation.
‡Additionally adjusted for tertiles of time spent active.
*p < .05, **p < .01, ***p < .001.