Table 2.
Event rates and relative risks for stroke, ischaemic stroke and haemorrhagic stroke, respectively, in 104 697 people with type 2 diabetes, stratified into four groups, depending on estimated glucose disposal rate (eGDR)
| Variable | eGDR (mg/kg/min) | Events/person-years | Rate per 1000 person-years (95% CI) |
Crude hazard ratio (95% CI) |
Age- and sex-adjusted hazard ratio (95% CI) | Multivariable adjusted* hazard ratio (95% CI) |
|---|---|---|---|---|---|---|
| All Stroke | < 4 | 1106/114389 | 9.7 (9.1–10.3) | 1.00 | 1.00 | 1.00 |
| 4–6 | 1847/194940 | 9.5 (9.0–9.9) | 0.97 (0.90–1.05) | 0.78 (0.73–0.84) | 0.77 (0.69–0.84) | |
| 6–8 | 771/100891 | 7.6 (7.1–8.2) | 0.79 (0.72–0.86) | 0.73 (0.67–0.81) | 0.68 (0.58–0.80) | |
| > 8 | 477/93028 | 5.1 (4.7–5.6) | 0.52 (0.47–0.58) | 0.59 (0.53–0.65) | 0.60 (0.48–0.76) | |
| Ischaemic stroke | < 4 | 912/114712 | 8.0 (7.4–8.5) | 1.00 | 1.00 | 1.00 |
| 4–6 | 1518/195541 | 7.8 (7.4–8.2) | 0.97 (0.90–1.05) | 0.78 (0.71–0.84) | 0.75 (0.67–0.84) | |
| 6–8 | 657/101133 | 6.5 (6.0–7.0) | 0.81 (0.73–0.90) | 0.75 (0.68–0.83) | 0.68 (0.57–0.81) | |
| > 8 | 389/93197 | 4.2 (3.8–4.6) | 0.52 (0.46–0.58) | 0.58 (0.51–0.65) | 0.55 (0.43–0.71) | |
| Haemorrhagic stroke | < 4 | 182/116550 | 1.6 (1.3–1.8) | 1.00 | 1.00 | 1.00 |
| 4–6 | 319/198339 | 1.6 (1.4–1.8) | 1.02 (0.85–1.22) | 0.85 (0.71–1.03) | 0.87 (0.69–1.10) | |
| 6–8 | 114/102320 | 1.1 (0.9–1.3) | 0.71 (0.56–0.89) | 0.72 (0.57–0.91) | 0.78 (0.53–1.15) | |
| > 8 | 93/93911 | 1.0 (0.8–1.2) | 0.62 (0.48–0.80) | 0.73 (0.57–0.93) | 1.07 (0.61–1.88) |
*Multivariable adjusted (see text statistics) not adjusted for variables including in the eGDR formula, i.e. HbA1c, waist circumference and blood pressure