Figure 2.

Schematic outline of the percentile ranking approach used to identify enriched gRNAs. To identify gRNAs that were significantly enriched in the lungs of the mice, the gRNAs found in the top 98th percentile of abundance in the lungs of each individual animal was determined. When comparing the percentile ranking results across all 3 cohorts (40 mice total), the gRNAs were then ranked by how often (i.e., in how many mice) they were detected, followed by their z-score.