Table 3.
GO/KEGG analysis of DEGs
| Term of GO/KEGG analysis | Count | P-Value | Genes |
|---|---|---|---|
| GO:0045893 ~ positive regulation of transcription, DNA-templated | 16 | 0.001254 | FZD1, HMGA1, BRCA1, MRPL12, HIF1A, MLLT11, ZXDA, LBH, TFAP4, MED13, CCNE1, BAMBI, MYC, CKS2, TASP1, MYBL1 |
| GO:0008283 ~ cell proliferation | 13 | 0.001433 | YAP1, UHRF1, ITGA2, FURIN, CENPF, KITLG, MYC, DDIT4, CKS2, KIF2C, TGFBI, GPC4, BCAT1 |
| GO:0007067 ~ mitotic nuclear division | 10 | 0.002886 | HELLS, CENPF, LATS2, TUBB3, RCC2, NEDD9, OIP5, KIF2C, CENPN, CEP55 |
| GO:0051301 ~ cell division | 11 | 0.009168 | HELLS, CENPF, LATS2, CCNE1, CDCA4, RCC2, KIF14, CKS2, NEDD9, OIP5, KIF2C |
| GO:0098609 ~ cell-cell adhesion | 8 | 0.042913 | TMEM47, LRRC59, GPRC5A, FASN, COBLL1, UBFD1, RANGAP1, PDLIM5 |
| GO:0005886 ~ plasma membrane | 69 | 0.000237 | ANKRD13B, TFRC, KIF14, GPR20, BRCA1, IGF1R, PPP1R9B, TMEM47, JPH2, ADORA3, BVES, SLC16A3, SLC36A1, SLC13A1, PRKCB, TRPC1, ITGA2, KCNK13, KCNAB1, PDIA6, SLC39A14, CKAP4, ENAH, FNDC5, SLC7A5, FNDC4, GPRC5A, ADCY9, PLSCR4, ITGA5, STX1A, MGLL, FAM84B, SLC24A2, SHC4, KANK1, SLC24A3, IGSF3, FURIN, SGMS2, SLC1A5, DLL1, LRP8, ADCY5, INPP5A, RAB23, DNAJB4, BTLA, TSPAN5, DMD, SLIT2, GPC4, CAMK2G, FZD1, CA12, KL, PRRT2, TMEM30B, DMPK, RCC2, CRIM1, OPRK1, TJAP1, KITLG, BAMBI, RAB15, FASN, TGFBI, RAB9B |
| GO:0005829 ~ cytosol | 58 | 0.000335 | CDKN1A, KIF14, MYLK, GLS, MYC, CHEK1, TK1, JAK2, PDE8B, PPFIA2, G6PD, PRKCB, KCNAB1, RANGAP1, PGD, ENAH, ITPKC, SLC7A5, ARHGEF9, DEPDC1B, LATS2, CCNE1, ALDH1A2, DDIT4, TRAF5, ALDH1A1, VAMP1, KIF2C, BCAT1, STX1A, MGLL, YAP1, PFKFB4, HSPA4L, GLRX, ABHD5, HIF1A, SRM, RACGAP1, DNAJB4, ABL2, DMD, PDLIM5, SRGAP1, CAMK2G, MAPK4, DYNC1I1, TBC1D16, DMPK, RCC2, HMGA1, TARBP2, CENPF, PSAT1, DNAJA4, FASN, CENPN, RAB9B |
| GO:0045202 ~ synapse | 9 | 0.000975 | ENAH, PRRT2, OPRK1, APBB2, DMD, MYRIP, ITGA5, CPEB2, PPFIA2 |
| GO:0016020 ~ membrane | 41 | 0.001156 | YAP1, SLC35B2, LRRC59, SFT2D3, TFRC, KIF14, FURIN, SLC1A5, LRP8, IPO4, IGF1R, EFTUD2, FYCO1, INPP5A, MED13, MLEC, STK38L, APBB2, SLIT2, JAK2, PDLIM5, SLC16A3, CAMK2G, CEP55, MPDU1, G6PD, PRRT2, RCC2, CKAP4, REEP1, SLC7A5, KITLG, MSH2, DNAJA4, FASN, MGAT4A, SRPRB, SFXN1, KIF2C, MGLL, FKBP5 |
| GO:0030027 ~ lamellipodium | 8 | 0.002131 | ENAH, KITLG, NEDD9, APBB2, SLC39A14, WASF3, MYLK, PPP1R9B |
| GO:0070062 ~ extracellular exosome | 45 | 0.010861 | TFRC, ARPC5L, FURIN, GLRX, SLC1A5, THSD4, TXNDC16, MYLK, INPP5A, RACGAP1, FGF9, PPP2R1B, CSRP1, TUBB3, RAB23, DNAJB4, CFL2, COBLL1, TIMP3, EFHD1, SLIT2, GPC4, WASF3, PPFIA2, MPDU1, KL, G6PD, PRKCB, H2AFX, CRIM1, PGD, SOD2, PDIA6, CKAP4, AIF1L, SLC7A5, GPRC5A, RAB15, PSAT1, FASN, MGAT4A, PLSCR4, ALDH1A1, TGFBI, FKBP5 |
| GO:0005737 ~ cytoplasm | 73 | 0.020204 | ANKRD13B, STEAP3, PID1, ARPC5L, BRCA1, WISP1, BACH2, IPO4, MYLK, PPP1R9B, EFTUD2, LBH, FGF9, TUBB3, OIP5, JAK2, PPFIA2, G6PD, PRKCB, RFX2, KCNAB1, RANGAP1, ENAH, SLC7A5, ARHGEF9, LATS2, NUP50, ALDH1A2, CRY2, DDIT4, TRAF5, ALDH1A1, MT1E, RBMS3, FAM84B, MCM2, YAP1, KANK1, CASZ1, HSPA4L, NEDD9, ABHD5, HIF1A, FAM117A, RACGAP1, RAB23, DNAJB4, HAS2, STK38L, APBB2, SLIT2, PDLIM5, SRGAP1, WASF3, MAPK4, DYNC1I1, USP25, CBX7, BDNF, ELL2, TARBP2, AIF1L, REEP1, MLLT11, KITLG, CENPF, ZDHHC9, PSAT1, BAMBI, RAB15, FASN, SRPRB, CPEB2 |
| GO:0005887 ~ integral component of plasma membrane | 25 | 0.025690 | SLC24A2, STEAP3, SLC24A3, TFRC, GPR20, SGMS2, SLC1A5, DLL1, IGF1R, HAS2, TSPAN5, TSPAN2, GPC4, SLC16A3, SLC13A1, KL, TRPC1, KCNK13, OPRK1, SLC39A14, SLC7A5, GPRC5A, ADCY9, SSPN, VAMP1 |
| GO:0019899 ~ enzyme binding | 11 | 0.004383 | MSH2, PLSCR4, H2AFX, HMGA1, MLEC, TSPAN5, BRCA1, HIF1A, TARBP2, MCM2, UNG |
| GO:0005515 ~ protein binding | 112 | 0.037391 | STEAP3, PID1, TFRC, IPO4, TXNDC16, MYLK, IGF1R, GLS, EFTUD2, ZXDA, PPP2R1B, TUBB3, MYC, CFL2, CHEK1, OIP5, BVES, SLC16A3, PPFIA2, G6PD, PRKCB, RFX2, PDIA6, MSH2, CCNE1, STX1A, FKBP5, SHC4, CDCA4, SLC1A5, MRPL12, HIF1A, INPP5A, RACGAP1, NACC2, ABL2, STK38L, TSPAN2, SRGAP1, MPDU1, TBC1D16, FZD1, CBX7, DMPK, VDR, RCC2, HMGA1, TJAP1, REEP1, FASN, TGFBI, CDKN1A, KIF14, BRCA1, PPP1R9B, FYCO1, JPH2, BCL7A, ADAMTSL3, TIMP3, TK1, JAK2, CEP55, HELLS, TRPC1, ITGA2, H2AFX, MYRIP, RANGAP1, ENAH, GPRC5A, LATS2, NUP50, PLSCR4, TRAF5, CRY2, CKS2, VAMP1, KIF2C, ITGA5, MCM2, FAM84B, YAP1, KANK1, UHRF1, NEDD9, FURIN, DLL1, LRP8, SRM, UNG, RAB23, DNAJB4, E2F2, APBB2, DMD, SLIT2, PDLIM5, CAMK2G, MAPK4, DYNC1I1, USP25, TMEM30B, OPRK1, C1ORF21, TARBP2, CENPF, KITLG, TFAP4, DNAJA4, RAB15, RAB9B |
| hsa05230:Central carbon metabolism in cancer | 7 | 0.000246 | SLC7A5, G6PD, MYC, SLC1A5, HIF1A, SLC16A3, GLS |
| hsa05200:Pathways in cancer | 16 | 0.000319 | FZD1, CDKN1A, PRKCB, ITGA2, HIF1A, ADCY5, IGF1R, KITLG, ADCY9, FGF9, MSH2, CCNE1, MYC, TRAF5, CKS2, E2F2 |
| hsa05205:Proteoglycans in cancer | 11 | 0.000441 | FZD1, CDKN1A, TFAP4, PRKCB, MYC, ITGA2, TIMP3, ITGA5, CAMK2G, HIF1A, IGF1R |
| hsa05214:Glioma | 6 | 0.002033 | SHC4, CDKN1A, PRKCB, E2F2, CAMK2G, IGF1R |
| hsa04114:Oocyte meiosis | 7 | 0.004406 | ADCY9, PPP2R1B, CCNE1, CPEB2, CAMK2G, IGF1R, ADCY5 |
| hsa05206:MicroRNAs in cancer | 11 | 0.006299 | SHC4, CDKN1A, CCNE1, PRKCB, MYC, DDIT4, TIMP3, E2F2, BRCA1, ITGA5, GLS |
| hsa05222:Small cell lung cancer | 6 | 0.006490 | CCNE1, MYC, ITGA2, TRAF5, CKS2, E2F2 |
| hsa04012:ErbB signaling pathway | 6 | 0.007153 | SHC4, CDKN1A, PRKCB, MYC, ABL2, CAMK2G |
| hsa04151:PI3K-Akt signaling pathway | 12 | 0.008276 | CDKN1A, KITLG, FGF9, PPP2R1B, CCNE1, MYC, ITGA2, DDIT4, BRCA1, ITGA5, JAK2, IGF1R |
| hsa04066:HIF-1 signaling pathway | 6 | 0.010730 | CDKN1A, TFRC, PRKCB, CAMK2G, HIF1A, IGF1R |
| hsa04916:Melanogenesis | 6 | 0.012655 | FZD1, KITLG, ADCY9, PRKCB, CAMK2G, ADCY5 |
| hsa04971:Gastric acid secretion | 5 | 0.018626 | ADCY9, PRKCB, CAMK2G, MYLK, ADCY5 |
| hsa04110:Cell cycle | 6 | 0.029203 | CDKN1A, CCNE1, MYC, CHEK1, E2F2, MCM2 |
| hsa05414:Dilated cardiomyopathy | 5 | 0.029430 | ADCY9, ITGA2, DMD, ITGA5, ADCY5 |
| hsa04911:Insulin secretion | 5 | 0.030563 | ADCY9, PRKCB, CAMK2G, STX1A, ADCY5 |
| hsa04310:Wnt signaling pathway | 6 | 0.043260 | FZD1, PRKCB, BAMBI, MYC, GPC4, CAMK2G |