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. 2021 Oct 6;21:1079. doi: 10.1186/s12885-021-08794-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Nuclear YAP enrichment and activity associate with the CIN marker pH2AX and poor clinical outcome. A Examples for YAP, TAZ and pH2AX positivity in human iCCA and dCCA cohorts. Bars: 50 μm. B Heatmap summarizing the expression of all CIN25 gene signature genes in an iCCA patient cohort. Expression data was divided into 3 groups by using the k-mean clustering algorithm (normal, cluster 1 and cluster 2). C Distribution of CIN25 gene signature is illustrated by the CIN gene score in normal bile duct tissue (Normal), Cluster 1 (low CIN gene signature score) and Cluster 2 (high CIN gene signature score). D Differences in overall survival of iCCA patients after median clustering of patients based on high or low relative expression of the CIN25 signature. Statistical test: Log-rank (Mantel-Cox)