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. 2021 Sep 23;27:1609926. doi: 10.3389/pore.2021.1609926

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Copyright © 2021 Radeczky, Moldvay, Fillinger, Szeitz, Ferencz, Boettiger, Rezeli, Bogos, Renyi-Vamos, Hoetzenecker, Hegedus, Megyesfalvi and Dome.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Primary tumor location and metastatic site in bone-metastatic LADC patients. (A) Peripherally located primary tumors are associated with femoral (OR 3.486, 95%CI 1.09–14.71, p = 0.022) and rib (OR 2.338, 95%CI 1.16–4.86, p = 0.012) metastases, whereas central LADCs give rise to humeral metastases (OR 0.262, 95%CI 0.06–0.83, p = 0.018). (B) Left-sided tumors are more frequently associated with skull metastases compared to right-sided primary LADCs (OR 4.836, 95%CI 1.19–28.19, p = 0.018). (C) No significant differences were found in metastasis pattern with regards to upper/middle lobe vs. lower lobe classification.